Marek Kochańczyk

Ph.D.,   Assistant Professor

Contact

e-mail at ippt.pan.pl or ucdavis.edu: mkochan
tel.: +48 22 8261280 ext. 161
room: 311

Institute of Fundamental Technological Research
Polish Academy of Sciences
Pawińskiego 5B, 02-106 Warsaw, Poland

Publications

Systems biology, cell signaling

• Non-self RNA rewires IFNβ signaling: A mathematical model of the innate immune response
  Korwek Z^☯, Czerkies M^☯, Jaruszewicz-Błońska J^☯, Prus W, Kosiuk I, Kochańczyk M^☯, Lipniacki T
  (submitted to Science Signaling) bioRxiv

• The MAPK/ERK channel capacity exceeds 6 bit/hour
  Nałęcz-Jawecki P, Gagliardi PA, Kochańczyk M, Dessauges C, Pertz O, Lipniacki T
  PLOS Computational Biology 19(5):e1011155 (2023)
  PubMed CrossRef bioRxiv Code Data

• Limits to the rate of information transmission through the MAPK pathway
  Grabowski F, Czyż P, Kochańczyk M^@, Lipniacki T^@
  Journal of the Royal Society Interface 16(152):20180792 (2019)
  PubMed CrossRef | PDF SuppCode

• Cell fate in antiviral response arises in the crosstalk of IRF, NF-κB and JAK/STAT pathways
  Czerkies M^☯, Korwek Z^☯, Prus W^☯, Kochańczyk M^☯, Jaruszewicz-Błońska J, Tudelska K, Błoński S, Kimmel M, Brasier AR, Lipniacki T
  Nature Communications 9:493 (2018)
  PubMed CrossRef | PDF SuppInfo-PDF SuppData SuppMovies SuppCode

• Information processing in the NF-κB pathway
  Tudelska K^☯, Markiewicz J^☯, Kochańczyk M^☯, Czerkies M, Prus W, Korwek Z, Abdi A, Błoński S, Kaźmierczak B, Lipniacki T
  Scientific Reports 7:15926 (2017)
  PubMed CrossRef | PDF SuppInfo-PDF SuppCode-BNGL SuppCode-Py

• RAF1/BRAF dimerization integrates the signal from RAS to ERK and ROKα
  Varga A, Ehrenreiter K, Aschenbrenner B, Kocieniewski P, Kochanczyk M, Lipniacki T, Baccarini M
  Science Signaling 10(469):eaai8482 (2017)
  PubMed CrossRef | SuppCode-BioNetGen

• Relaxation oscillations and hierarchy of feedbacks in MAPK signaling
  Kochańczyk M^@, Kocieniewski P, Kozłowska E, Jaruszewicz-Błońska J, Sparta B, Pargett M, Albeck JG, Hlavacek WS, Lipniacki T^@
  Scientific Reports 7:38244 (2017)
  PubMed CrossRef | PDF SuppInfo-PDF SuppCode-BNG SuppCode-MatCont SuppCode-BNG-noisy SuppCode-Comsol SuppMovie

• Importins promote high-frequency NF-κB oscillations increasing information channel capacity
  Korwek Z, Tudelska K, Nałęcz-Jawecki P, Czerkies M, Prus W, Markiewicz J, Kochańczyk M, Lipniacki T
  Biology Direct 11:61 (2016)
  PubMed CrossRef | PDF Scheme-PDF SuppModelInfo-PDF SuppModelCode-BNGL SuppFigs-PDF SuppImages-ZIP

• Feedbacks, bifurcations, and cell fate decision-making in the p53 system
  Hat B^☯, Kochańczyk M^☯, Bogdał M, Lipniacki T
  PLOS Computational Biology 12(2):e1004787 (2016)
  PubMed CrossRef | PDF SuppText SuppFigs SuppCode

• A mathematical model of bimodal epigenetic control of miR-193a in ovarian cancer stem cells
  Cheng FHC, Aguda BD, Tsai J-C, Kochańczyk M, Lin JMJ, Chen GCW, Lai H-C, Nephew KP, Hwang T-W, Chan MWY
  PLOS One 9(12):e116050 (2014)
  PubMed CrossRef | PDF

• Levels of pro-apoptotic regulator Bad and anti-apoptotic regulator Bcl-xL determine the type of the apoptotic logic gate
  Bogdał MN, Hat B, Kochańczyk M, Lipniacki T
  BMC Systems Biology 7:67 (2013)
  PubMed CrossRef | PDF Code-Matlab

• Spontaneous NF-κB activation by autocrine TNFα signaling: A computational analysis
  Pękalski J, Zuk PJ, Kochańczyk M, Junkin M, Kellog R, Tay S, Lipniacki T
  PLOS One 8(11):e78887 (2013)
  PubMed CrossRef | PDF Supp-PDF Code-Matlab Code-BioNetGen Code-MatCont

Virology, epidemiology, public health

• Antagonism between viral infection and innate immunity at the single-cell level
  Grabowski F^☯, Kochańczyk M^☯, Korwek Z, Czerkies M, Prus W, Lipniacki T.
  PLOS Pathogens 19(9):e1011597 (2023)
  CrossRef bioRxiv Code Data

• Respiratory syncytial virus protects bystander cells against influenza A virus infection by triggering secretion of type I and type III interferons
  Czerkies M^☯, Kochańczyk M^☯, Korwek Z, Prus W, Lipniacki T.
  Journal of Virology 96:22 e01341-22 (2022)
  PubMed CrossRef bioRxiv

• The spread of SARS-CoV-2 variant Omicron with the doubling time of 2.0–3.3 days can be explained by immune evasion
  Grabowski F, Kochańczyk M, Lipniacki T.
  Viruses 14(2):294 (2022)
  PubMed CrossRef medRxiv | PDF Correspondence

• SARS-CoV-2 Variant of Concern 202012/01 has about twofold replicative advantage and acquires concerning mutations
  Grabowski F^☯, Preibisch G, Giziński S, Kochańczyk M^☯,@, Lipniacki T^@
  Viruses 13(3):392 (2021)
  PubMed CrossRef medRxiv | PDF SuppInfo-ZIP Correspondence

• Pareto-based evaluation of national responses to COVID-19 pandemic shows that saving lives and protecting economy are non-trade-off objectives
  Kochańczyk M^@, Lipniacki T
  Scientific Reports 11:2425 (2021)
  PubMed CrossRef medRxiv | PDF GitHub

• Super-spreading events initiated the exponential growth phase of COVID-19 with R₀ higher than initially estimated
  Kochańczyk M, Grabowski F, Lipniacki T
  Royal Society Open Science 7:200786 (2020)
  PubMed CrossRef | PDF SuppInfo-PDF Correspondence

• Dynamics of COVID-19 pandemic at constant and time-dependent contact rates
  Kochańczyk M, Grabowski F, Lipniacki T
  Mathematical Modelling of Natural Phenomena 15:28 (2020)
  CrossRef | PDF SuppCode

Chemical physics, biophysics

• Sampling rare events in stochastic reaction–diffusion systems within trajectory looping
  Zuk PJ^☯, Kochańczyk M^☯, Lipniacki T
  Physical Review E 98:022401 (2018)
  PubMed CrossRef | PDF-ms Www

• Effective reaction rates for diffusion-limited reaction cycles
  Nałęcz-Jawecki P, Szymańska P, Kochańczyk M, Miękisz J, Lipniacki T
  Journal of Chemical Physics 143(21):215102 (2015)
  PubMed CrossRef | PDF-ms

• Effective reaction rates in diffusion-limited phosphorylation–dephosphorylation cycles
  Szymańska P^☯, Kochańczyk M^☯, Miękisz J, Lipniacki T
  Physical Review E 91:022702 (2015)
  PubMed CrossRef | PDF-ms

• Stochastic transitions in a bistable reaction system on the membrane
  Kochańczyk M, Jaruszewicz J, Lipniacki T
  Journal of the Royal Society Interface 10(84):20130151 (2013)
  PubMed CrossRef | PDF Supp-PDF Supp-movies

• Dynamics of a stochastic spatially extended system predicted by comparing deterministic and stochastic attractors of the corresponding birth–death process
  Żuk PJ, Kochańczyk M, Jaruszewicz J, Bednorz W, Lipniacki T
  Physical Biology 5(9):055002 (2012)
  PubMed CrossRef | PDF-ms

Computational structural biology

• Prediction of functionally important residues in globular proteins from unusual central distances of amino acids
  Kochańczyk M
  BMC Structural Biology 11(1):34 (2011)
  PubMed CrossRef | PDF PDF+supp Code Server

• In silico structural study of random amino acid sequence proteins not present in nature
  Prymula K, Piwowar M, Kochańczyk M, Flis L, Malawski M, Szepieniec T, Evangelista G, Minervini G, Polticelli F, Wiśniowski Z, Sałapa K, Matczyńska E, Roterman I
  Chemistry & Biodiversity 6(12):2311–2336 (2009)
  PubMed CrossRef

• Prediction of functional sites based on the fuzzy oil drop model
  Bryliński M, Prymula K, Jurkowski W, Kochańczyk M, Stawowczyk E, Konieczny L, Roterman I
  PLoS Computational Biology 3(5):e94 (2007)
  PubMed CrossRef | PDF

• Localization of ligand binding site in proteins identified in silico
  Bryliński M, Kochańczyk M, Broniatowska E, Roterman I
  Journal of Molecular Modeling 13(6–7):665–675 (2007)
  PubMed CrossRef

Software tools

• Spatkin: a simulator for rule-based modeling of biomolecular site dynamics on surfaces
  Kochańczyk M^@, Hlavacek WS, Lipniacki T
  Bioinformatics 33(22):3667–3669 (2017)
  PubMed CrossRef | Www

• ShuttleTracker: a tool for analysing nucleocytoplasmic shuttling of fluorescent reporters
  (unpublished) Www